UAP1

Across TCGA pan-cancer cohorts, UAP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UAP1 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher UAP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UAP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where UAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.684	0.925	<.001	82	view →
PDAC	DFS	Tertile	II,III,IV	0.513	0.227	.003	17	view →
LSCC	DFS	Median	II,III,IV	0.503	0.890	.001	16	view →
HNSC	OS	Quartile	III,IV	0.608	0.941	.010	13	view →
UCEC	DFS	Median	II,III,IV	0.872	0.543	.038	4	view →
GBM	DFS	Tertile	All	0.263	0.482	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UAP1–CCRCC (DFS)

Open the CCRCC breakdown →