UAP1

Across TCGA patient cohorts, UAP1 mutation is significantly associated with the RNA expression of many other genes, with 1,087 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UAP1-associated genes across cancer lineages are MIR4803, UQCRFS1P3, and RNA5SP436. Each is linked with UAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UAP1-to-partner and partner-to-UAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4803 grouped by UAP1-low versus UAP1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UAP1→partner) and Y-score (partner→UAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4803 →	+0.551	+6.382	<.001	.001	3	2
SKCM	UQCRFS1P3 →	+0.182	+4.302	<.001	.002	3	2
UCEC	RNA5SP436 →	+0.270	+2.937	<.001	.002	3	2
UCEC	RNU6-718P →	+0.126	+3.374	.001	.003	3	2
COAD	RNU6-1252P →	+0.526	+7.741	<.001	.009	3	2
COAD	TEX101P1 →	+0.186	+7.741	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,087 associations by consensus.

MIR4803 by UAP1 expression — BRCA

Explore this box plot interactively →