UAP1

Across TCGA patient cohorts, UAP1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UAP1-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and JNK_pT183_Y185. Each is linked with UAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UAP1-to-partner and partner-to-UAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by UAP1-low versus UAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UAP1→partner) and Y-score (partner→UAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.215	-2.222	.043	.011	3	1
UCEC	eIF4G →	+0.270	+1.700	.040	.044	3	1
UCEC	JNK_pT183_Y185 →	-0.188	-2.893	.008	.001	3	1
UCEC	JNK2 →	+0.283	+3.196	<.001	.009	3	1
UCEC	NDRG1_pT346 →	-0.530	-3.321	.010	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.464	-2.321	.015	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by UAP1 expression — UCEC

Explore this box plot interactively →