UACA

Across TCGA pan-cancer cohorts, UACA mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated UACA data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher UACA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UACA expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where UACA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.667	1.000	.001	32	view →
PDAC	OS	Tertile	II,III,IV	0.967	0.716	.005	27	view →
HNSC	OS	Median	IV	0.889	0.599	.002	15	view →
CCRCC	DFS	Quartile	III,IV	0.814	0.345	.004	12	view →
UCEC	DFS	Tertile	All	0.927	0.743	.034	6	view →
LSCC	DFS	Quartile	II,III,IV	0.892	0.203	.024	6	view →
GBM	OS	Quartile	All	0.754	0.985	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

UACA–LUAD (DFS)

Open the LUAD breakdown →