UACA

Across TCGA cell cohorts, UACA mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UACA-associated genes across cancer lineages are FCRL2, OR1L4, and MS4A6E. Each is linked with UACA in more than 1 cancer types. Because this analysis shows association rather than direction, both UACA-to-partner and partner-to-UACA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCRL2 grouped by UACA-low versus UACA-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UACA→partner) and Y-score (partner→UACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FCRL2 →	+0.143	+3.906	<.001	.006	3	1
CNS	OR1L4 →	+0.188	+3.643	<.001	.007	3	1
CNS	MS4A6E →	+0.418	+4.044	<.001	.003	3	1
CNS	MMP26 →	+0.103	+4.169	<.001	.008	3	1
CNS	OR13C2 →	+0.007	+4.169	<.001	.008	3	1
LARGE_INTESTINE	NPHS2 →	+0.065	+2.859	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

FCRL2 by UACA expression — CNS

Explore this box plot interactively →