U2AF2

Across TCGA pan-cancer cohorts, U2AF2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated U2AF2 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher U2AF2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated U2AF2 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

HNSC, COAD, and LUAD are the cancer types where U2AF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.132	1.000	.010	44	view →
COAD	DFS	Median	All	1.000	0.893	.030	12	view →
LUAD	DFS	Tertile	II,III,IV	0.937	0.641	.014	10	view →
OV	DFS	Median	All	0.874	1.000	.049	4	view →
PDAC	DFS	Quartile	All	0.470	0.326	.038	2	view →
CCRCC	DFS	Tertile	All	0.875	0.973	.025	2	view →
LSCC	DFS	Median	III,IV	0.882	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

U2AF2–HNSC (OS)

Open the HNSC breakdown →