U2AF1

Across TCGA patient cohorts, U2AF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,043 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible U2AF1-associated GO terms across cancer lineages are Termination of RNA polymerase II transcription, Peptidyl-lysine acetylation, and Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Each is linked with U2AF1 in more than 30 cancer types. Because this analysis shows association rather than direction, both U2AF1-to-partner and partner-to-U2AF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Termination of RNA polymerase II transcription grouped by U2AF1-low versus U2AF1-high in DLBC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (U2AF1→partner) and Y-score (partner→U2AF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	Termination of RNA polymerase II transcription →	+0.074	+0.328	<.001	<.001	3	30
KIRC	Peptidyl-lysine acetylation →	+0.050	+0.330	<.001	<.001	3	30
STAD	Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.049	+0.280	<.001	<.001	3	30
STAD	Regulation of chromosome organization →	+0.055	+0.306	<.001	<.001	3	30
STAD	Protein acylation →	+0.045	+0.263	<.001	<.001	3	30
KIRC	Glycerophospholipid biosynthetic process →	+0.035	+0.344	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,043 associations by consensus.

Termination of RNA polymerase II transcription by U2AF1 expression — DLBC

Explore this box plot interactively →