U2AF1

Across TCGA cell cohorts, U2AF1 mutation is significantly associated with the drug of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible U2AF1-associated genes across cancer lineages are Erlotinib, BMS-345541, and Cyclophosphamide. Each is linked with U2AF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both U2AF1-to-partner and partner-to-U2AF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Erlotinib grouped by U2AF1-low versus U2AF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (U2AF1→partner) and Y-score (partner→U2AF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Erlotinib →	+0.629	+2.777	.013	.038	2	1
LARGE_INTESTINE	BMS-345541 →	+0.536	+2.646	.034	.047	2	1
LARGE_INTESTINE	Cyclophosphamide →	+0.348	+2.649	.026	.046	2	1
LARGE_INTESTINE	Camptothecin →	+0.586	+2.646	.047	.047	1	1
LARGE_INTESTINE	Niraparib →	+0.360	+2.646	.043	.047	1	1
LARGE_INTESTINE	EPZ5676 →	+0.445	+2.769	.012	.040	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Erlotinib by U2AF1 expression — LARGE_INTESTINE

Explore this box plot interactively →