TYW3

Across TCGA pan-cancer cohorts, TYW3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TYW3 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TYW3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TYW3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where TYW3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.900	1.000	.005	28	view →
PDAC	DFS	Tertile	II,III,IV	0.582	0.323	.014	10	view →
LUAD	DFS	Median	II,III,IV	1.000	0.785	.024	5	view →
GBM	OS	Median	All	0.279	0.521	.007	5	view →
LSCC	OS	Quartile	All	0.861	0.615	.024	4	view →
CCRCC	OS	Quartile	All	0.799	0.994	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TYW3–HNSC (DFS)

Open the HNSC breakdown →