TYW3

Across TCGA patient cohorts, TYW3 mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible TYW3-associated genes across cancer lineages are RPL7P35, ISCA1P2, and LCE1D. Each is linked with TYW3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TYW3-to-partner and partner-to-TYW3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL7P35 grouped by TYW3-low versus TYW3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYW3→partner) and Y-score (partner→TYW3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL7P35 →	+0.097	+2.842	.006	.007	3	2
BLCA	ISCA1P2 →	+0.098	+4.558	<.001	.001	3	2
UCEC	LCE1D →	+0.072	+4.069	<.001	.008	3	1
BRCA	AGGF1P8 →	+0.084	+5.883	<.001	.003	3	1
BRCA	OR1P1 →	+0.136	+5.096	<.001	.008	3	1
BRCA	RN7SL616P →	+0.276	+5.883	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

RPL7P35 by TYW3 expression — UCEC

Explore this box plot interactively →