TYW3

Across TCGA cell cohorts, TYW3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,275 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TYW3-associated GO terms across cancer lineages are Positive regulation of centriole replication, DNA replication checkpoint signaling, and IMP biosynthetic process. Each is linked with TYW3 in more than 13 cancer types. Because this analysis shows association rather than direction, both TYW3-to-partner and partner-to-TYW3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of centriole replication grouped by TYW3-low versus TYW3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TYW3→partner) and Y-score (partner→TYW3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of centriole replication →	+0.130	+0.924	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA replication checkpoint signaling →	+0.124	+0.785	.009	.002	3	12
OVARY	IMP biosynthetic process →	+0.176	+0.700	<.001	<.001	3	11
LUNG_NSCLC_LUSC	DNA replication initiation →	+0.152	+0.685	.002	.003	3	11
SOFT_TISSUE	Centriole replication →	+0.083	+0.601	.001	<.001	3	11
STOMACH	Mitochondrial RNA 3'-end processing →	+0.098	+0.782	.003	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,275 associations by consensus.

Positive regulation of centriole replication by TYW3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →