TYW3

Across TCGA cell cohorts, TYW3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,956 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TYW3-associated genes across cancer lineages are BRMS1, METTL16, and INTS2. Each is linked with TYW3 in more than 4 cancer types. Because this analysis shows association rather than direction, both TYW3-to-partner and partner-to-TYW3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TYW3 versus BRMS1 in UPPER_AERODIGESTIVE_TRACT, with a Pearson correlation of -0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYW3→partner) and Y-score (partner→TYW3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	BRMS1 →	-1.153	-2.296	<.001	.008	3	5
CNS	METTL16 →	-0.537	-1.400	<.001	<.001	3	4
LUNG_NSCLC_LUAD	INTS2 →	-1.002	-1.598	.008	.004	3	3
LUNG_NSCLC_LUAD	ODF2 →	-1.341	-1.801	<.001	.005	3	3
LUNG_NSCLC_LUAD	ZNF432 →	-1.082	-1.188	.003	.003	3	3
BONE	METAP2 →	-0.673	-2.810	.007	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,956 associations by consensus.

TYW3 vs BRMS1 — UPPER_AERODIGESTIVE_TRACT

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