TYW1B

Across TCGA pan-cancer cohorts, TYW1B Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TYW1B data layer compared with 21 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher TYW1B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TYW1B expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

CESC, UCEC, and COAD are the cancer types where TYW1B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	III,IV	0.203	0.765	<.001	18	view →
UCEC	DFS	Median	II,III,IV	0.885	0.430	.017	16	view →
COAD	DFS	Median	All	0.197	0.699	<.001	14	view →
LGG	DFS	Median	All	0.110	0.833	<.001	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
SKCM	DFS	Median	All	0.553	0.197	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TYW1B–CESC (OS)

Open the CESC breakdown →