TYW1B

Across TCGA patient cohorts, TYW1B mutation is significantly associated with the RNA expression of many other genes, with 4,536 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TYW1B-associated genes across cancer lineages are RNU1-1, OR51A7, and OR11J5P. Each is linked with TYW1B in more than 3 cancer types. Because this analysis shows association rather than direction, both TYW1B-to-partner and partner-to-TYW1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-1 grouped by TYW1B-low versus TYW1B-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYW1B→partner) and Y-score (partner→TYW1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	RNU1-1 →	+0.966	+3.134	<.001	.007	3	4
STAD	OR51A7 →	+0.304	+3.853	<.001	.008	3	3
PRAD	OR11J5P →	+0.194	+4.427	<.001	.005	3	3
KIRP	NPS →	+0.428	+5.528	<.001	.002	3	3
COAD	TRBV11-3 →	+0.451	+3.627	.003	.008	3	3
UCEC	TRAJ57 →	+0.273	+1.690	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,536 associations by consensus.

RNU1-1 by TYW1B expression — PRAD

Explore this box plot interactively →