Across TCGA pan-cancer cohorts, TYW1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TYW1 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TYW1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TYW1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where TYW1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	0.507	0.977	.010	19	view →
PDAC	DFS	Tertile	All	0.291	0.577	.013	17	view →
LUAD	DFS	Tertile	II,III,IV	0.262	0.641	.036	6	view →
LSCC	OS	Median	II,III,IV	1.000	0.897	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TYW1 tumor-vs-normal RNA expression · all TYW1 data types