Across TCGA patient cohorts, TYW1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TYW1-associated genes across cancer lineages are CDK1, 4E-BP1, and Cyclin-B1. Each is linked with TYW1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TYW1-to-partner and partner-to-TYW1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYW1→partner) and Y-score (partner→TYW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDK1 →	+0.154	+2.183	.006	.033	3	2
UCEC	4E-BP1 →	+0.328	+2.614	.001	.005	3	2
COAD	Cyclin-B1 →	+0.615	+2.815	.039	.036	3	2
UCEC	Di-Ras3 →	-0.173	-3.446	.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.169	.005	.003	3	1
UCEC	A-Raf_pS299 →	-0.158	-3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

TYW1 survival (RNA) · tumor vs normal (RNA) · all TYW1 data types