Across TCGA cell cohorts, TYW1 mutation is significantly associated with the RNA expression of many other genes, with 188 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TYW1-associated genes across cancer lineages are FBXW4, C1QBP, and DPH1. Each is linked with TYW1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TYW1-to-partner and partner-to-TYW1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYW1→partner) and Y-score (partner→TYW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW4 →	+0.874	+3.169	<.001	.006	3	1
LARGE_INTESTINE	C1QBP →	+0.714	+3.131	.001	.008	3	1
LARGE_INTESTINE	DPH1 →	+0.640	+3.364	.008	.002	3	1
LARGE_INTESTINE	BCL7A →	+0.785	+3.169	.004	.009	3	1
LARGE_INTESTINE	TTF2 →	+0.686	+3.364	.002	.002	3	1
LARGE_INTESTINE	ACTL8 →	+1.566	+3.364	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 188 associations by consensus.

Exploration

TYW1 survival (RNA) · tumor vs normal (RNA) · all TYW1 data types