TYR

Across TCGA patient cohorts, TYR mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TYR-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and ASNS. Each is linked with TYR in more than 4 cancer types. Because this analysis shows association rather than direction, both TYR-to-partner and partner-to-TYR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TYR-low versus TYR-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYR→partner) and Y-score (partner→TYR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Caspase-7-cleavedD198 →	+0.702	+2.816	.010	.036	3	5
LUSC	4E-BP1 →	+0.592	+2.821	.005	.035	3	4
COAD	ASNS →	+0.550	+3.000	.004	.035	3	4
LUAD	14-3-3_zeta →	+0.505	+2.807	.001	.003	3	3
LUAD	Nrf2 →	+0.191	+2.183	.007	.033	3	2
LUAD	STAT3_pY705 →	-0.368	-2.807	<.001	.003	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by TYR expression — LUSC

Explore this box plot interactively →