TYR

Across TCGA cell cohorts, TYR mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TYR-associated genes across cancer lineages are FCRL4, NCR1, and PRB1. Each is linked with TYR in more than 1 cancer types. Because this analysis shows association rather than direction, both TYR-to-partner and partner-to-TYR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCRL4 grouped by TYR-low versus TYR-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYR→partner) and Y-score (partner→TYR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FCRL4 →	+0.010	+4.058	<.001	.007	3	1
LUNG_SCLC	NCR1 →	+0.068	+3.817	<.001	.004	3	1
LUNG_SCLC	PRB1 →	+0.028	+3.523	.002	.008	3	1
LUNG_SCLC	ADORA3 →	+0.221	+3.523	<.001	.008	3	1
BLOOD_Lymphoma	CPA3 →	+0.015	+4.606	.009	.001	3	1
BLOOD_Lymphoma	TAAR9 →	+0.047	+3.714	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FCRL4 by TYR expression — LUNG_SCLC

Explore this box plot interactively →