TYMP

Across TCGA pan-cancer cohorts, TYMP mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TYMP’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where TYMP mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TYMP is over-expressed in tumor.

CCRCC, COAD, and HNSC are the cancer types where TYMP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TYMP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	+1.647	<.001	12	view →
COAD	Female	III,IV	+0.489	<.001	11	view →
HNSC	Male	All	+0.963	<.001	8	view →
PDAC	Female	All	+0.841	<.001	8	view →
LUAD	Female	All	+0.286	<.001	8	view →
LSCC	Female	All	+0.446	<.001	7	view →
OV	All	All	+0.534	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

TYMP–CCRCC

Open the CCRCC breakdown →