Across TCGA pan-cancer cohorts, TXNRD3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TXNRD3 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TXNRD3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TXNRD3 expression acts as an unfavorable survival marker.

BRCA, UCEC, and COAD are the cancer types where TXNRD3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.657	0.924	.014	16	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	OS	Median	II,III,IV	0.168	0.788	.005	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TXNRD3 tumor-vs-normal RNA expression · all TXNRD3 data types