Across TCGA pan-cancer cohorts, TXNRD3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TXNRD3 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TXNRD3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TXNRD3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where TXNRD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.326	1.000	.036	13	view →
UCEC	OS	Median	II,III,IV	0.647	1.000	.017	8	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.514	.022	4	view →
LUAD	DFS	Median	III,IV	0.325	0.732	.028	3	view →
LSCC	DFS	Median	III,IV	0.882	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TXNRD3 tumor-vs-normal RNA expression · all TXNRD3 data types