Across TCGA patient cohorts, TXNRD3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNRD3-associated genes across cancer lineages are N-Cadherin, Notch1, and CD49b. Each is linked with TXNRD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNRD3-to-partner and partner-to-TXNRD3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNRD3→partner) and Y-score (partner→TXNRD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	N-Cadherin →	+0.271	+3.169	.002	.018	3	2
UCEC	Notch1 →	+0.177	+3.179	.003	.010	3	2
UCEC	CD49b →	-0.335	-2.439	.005	.019	3	2
UCEC	C-Raf →	+0.185	+2.584	.002	.010	3	2
UCEC	eEF2 →	+0.446	+2.906	.003	.001	3	1
UCEC	EGFR_pY1068 →	-0.326	-2.906	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Exploration

TXNRD3 survival (RNA) · tumor vs normal (RNA) · all TXNRD3 data types