Across TCGA pan-cancer cohorts, TXNRD2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TXNRD2 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TXNRD2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TXNRD2 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where TXNRD2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.880	.019	12	view →
CCRCC	DFS	Tertile	II,III,IV	0.425	0.873	.007	10	view →
PDAC	OS	Median	II,III,IV	0.940	0.725	.024	4	view →
LUAD	OS	Median	III,IV	0.750	0.997	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TXNRD2 tumor-vs-normal RNA expression · all TXNRD2 data types