Across TCGA patient cohorts, TXNRD2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNRD2-associated genes across cancer lineages are Lck, mTOR_pS2448, and ASNS. Each is linked with TXNRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNRD2-to-partner and partner-to-TXNRD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNRD2→partner) and Y-score (partner→TXNRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.253	+1.584	.001	.036	3	2
UCEC	mTOR_pS2448 →	-0.152	-3.565	.009	.002	3	2
UCEC	ASNS →	+0.540	+2.459	<.001	.018	3	2
UCEC	eEF2 →	+0.418	+3.169	.002	.018	3	1
UCEC	EGFR_pY1068 →	-0.199	-1.584	.043	.036	3	1
UCEC	eIF4E →	+0.177	+2.700	.032	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

TXNRD2 survival (RNA) · tumor vs normal (RNA) · all TXNRD2 data types