Across TCGA cell cohorts, TXNRD2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TXNRD2-associated genes across cancer lineages are OR2V2, PRAMEF33, and LBHD2. Each is linked with TXNRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNRD2-to-partner and partner-to-TXNRD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNRD2→partner) and Y-score (partner→TXNRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2V2 →	+0.029	+3.544	<.001	.009	3	2
SKIN	PRAMEF33 →	+0.023	+5.415	<.001	.004	3	1
LARGE_INTESTINE	LBHD2 →	+0.094	+3.688	<.001	.002	3	1
LARGE_INTESTINE	SPEM3 →	+0.013	+3.347	<.001	.005	3	1
LARGE_INTESTINE	NEXMIF →	+0.202	+3.196	.001	.007	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

TXNRD2 survival (RNA) · tumor vs normal (RNA) · all TXNRD2 data types