Across TCGA pan-cancer cohorts, TXNRD1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TXNRD1 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TXNRD1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TXNRD1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, KIRP, and STAD are the cancer types where TXNRD1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.968	0.609	.005	34	view →
KIRP	OS	Median	All	0.184	0.885	<.001	15	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
SKCM	DFS	Median	All	0.355	0.736	<.001	6	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TXNRD1 tumor-vs-normal RNA expression · all TXNRD1 data types