Across TCGA patient cohorts, TXNRD1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNRD1-associated genes across cancer lineages are ASNS, FASN, and FoxM1. Each is linked with TXNRD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TXNRD1-to-partner and partner-to-TXNRD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNRD1→partner) and Y-score (partner→TXNRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.454	+1.716	<.001	.003	3	3
UCEC	FASN →	+0.285	+1.807	.025	.025	3	2
UCEC	FoxM1 →	+0.304	+2.000	<.001	<.001	3	2
UCEC	JNK2 →	+0.241	+1.716	<.001	.003	3	2
UCEC	MEK1 →	+0.488	+3.169	<.001	<.001	3	2
UCEC	Mre11 →	-0.065	-1.673	.019	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration

TXNRD1 survival (RNA) · tumor vs normal (RNA) · all TXNRD1 data types