Across TCGA cell cohorts, TXNRD1 mutation is significantly associated with the RNA expression of many other genes, with 269 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TXNRD1-associated genes across cancer lineages are TRMU, SLC25A35, and APCS. Each is linked with TXNRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNRD1-to-partner and partner-to-TXNRD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNRD1→partner) and Y-score (partner→TXNRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRMU →	+0.625	+3.364	.001	.002	3	2
LARGE_INTESTINE	SLC25A35 →	+0.744	+3.067	.003	.009	3	2
LUNG_NSCLC_LUSC	APCS →	+0.129	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	ATP6V1G3 →	+0.260	+4.108	.001	.005	3	1
BLOOD_Leukemia	BTBD16 →	+0.053	+2.696	.001	.008	3	1
BLOOD_Leukemia	PROK1 →	+0.161	+2.829	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 269 associations by consensus.

Exploration

TXNRD1 survival (RNA) · tumor vs normal (RNA) · all TXNRD1 data types