TXNDC9

Across TCGA pan-cancer cohorts, TXNDC9 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TXNDC9 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TXNDC9 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TXNDC9 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

CCRCC, UCEC, and PDAC are the cancer types where TXNDC9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.633	0.832	.004	26	view →
UCEC	DFS	Tertile	III,IV	0.847	0.232	.023	8	view →
PDAC	OS	Median	II,III,IV	0.719	0.934	.010	7	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
LUAD	OS	Tertile	All	0.552	0.920	.007	6	view →
HNSC	OS	Median	All	0.992	0.942	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TXNDC9–CCRCC (DFS)

Open the CCRCC breakdown →