TXNDC5

Across TCGA pan-cancer cohorts, TXNDC5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TXNDC5 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TXNDC5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TXNDC5 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where TXNDC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.639	1.000	.003	25	view →
PDAC	OS	Tertile	II,III,IV	0.591	0.271	.010	20	view →
LSCC	DFS	Quartile	II,III,IV	0.523	0.857	.015	9	view →
GBM	DFS	Tertile	All	0.661	0.879	.015	6	view →
HNSC	OS	Quartile	II,III,IV	0.925	1.000	.032	5	view →
LUAD	DFS	Quartile	II,III,IV	0.866	0.229	.007	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TXNDC5–CCRCC (OS)

Open the CCRCC breakdown →