TXNDC5

Across TCGA cell cohorts, TXNDC5 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TXNDC5-associated genes across cancer lineages are ICOS, PRB1, and HPCAL4. Each is linked with TXNDC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNDC5-to-partner and partner-to-TXNDC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ICOS grouped by TXNDC5-low versus TXNDC5-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC5→partner) and Y-score (partner→TXNDC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ICOS →	+0.017	+3.938	<.001	.005	3	1
OVARY	PRB1 →	+0.055	+4.263	<.001	.002	3	1
LARGE_INTESTINE	HPCAL4 →	+0.390	+3.392	<.001	.004	3	1
LARGE_INTESTINE	ITGAD →	+0.010	+2.832	<.001	.002	3	1
LARGE_INTESTINE	LGI3 →	+0.333	+3.392	<.001	.003	3	1
LARGE_INTESTINE	TNK1 →	+0.849	+3.064	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ICOS by TXNDC5 expression — OVARY

Explore this box plot interactively →