TXNDC2

Across TCGA pan-cancer cohorts, TXNDC2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TXNDC2 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TXNDC2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TXNDC2 expression acts as an unfavorable survival marker.

HNSC, CESC, and PRAD are the cancer types where TXNDC2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.201	0.679	.002	12	view →
CESC	DFS	Median	II,III,IV	0.193	0.705	.045	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	6	view →
LGG	OS	Median	All	0.407	0.799	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TXNDC2–HNSC (OS)

Open the HNSC breakdown →