TXNDC2

Across TCGA patient cohorts, TXNDC2 mutation is significantly associated with the RNA expression of many other genes, with 2,090 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNDC2-associated genes across cancer lineages are COPRSP1, MIRLET7F1, and RNU6-178P. Each is linked with TXNDC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TXNDC2-to-partner and partner-to-TXNDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPRSP1 grouped by TXNDC2-low versus TXNDC2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC2→partner) and Y-score (partner→TXNDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	COPRSP1 →	+0.086	+3.653	<.001	.009	3	3
HNSC	MIRLET7F1 →	+0.461	+3.342	<.001	.007	3	2
HNSC	RNU6-178P →	+0.295	+3.478	.001	.008	3	2
HNSC	SERPINB8P1 →	+0.088	+4.936	<.001	.003	3	2
READ	GMNC →	+0.204	+4.176	<.001	.001	3	2
READ	RNU6-767P →	+0.654	+3.906	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,090 associations by consensus.

COPRSP1 by TXNDC2 expression — CESC

Explore this box plot interactively →