TXNDC2

Across TCGA patient cohorts, TXNDC2 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNDC2-associated genes across cancer lineages are ASNS, eIF4E, and FASN. Each is linked with TXNDC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TXNDC2-to-partner and partner-to-TXNDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TXNDC2-low versus TXNDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC2→partner) and Y-score (partner→TXNDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.324	+1.765	.006	.013	3	3
UCEC	eIF4E →	+0.231	+2.643	<.001	<.001	3	2
UCEC	FASN →	+0.304	+3.321	.019	.009	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.525	+3.009	.001	<.001	3	2
UCEC	Myosin-IIa_pS1943 →	+0.245	+1.665	<.001	.003	3	2
UCEC	PARP_cleaved →	-0.221	-2.115	.029	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

ASNS by TXNDC2 expression — UCEC

Explore this box plot interactively →