TXNDC2

Across TCGA cell cohorts, TXNDC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,453 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TXNDC2-associated GO terms across cancer lineages are Regulation of cell-substrate adhesion, Regulation of cell-substrate junction organization, and Positive regulation of supramolecular fiber organization. Each is linked with TXNDC2 in more than 9 cancer types. Because this analysis shows association rather than direction, both TXNDC2-to-partner and partner-to-TXNDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate adhesion grouped by TXNDC2-low versus TXNDC2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC2→partner) and Y-score (partner→TXNDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate adhesion →	+0.128	+0.318	<.001	.002	3	10
BONE	Regulation of cell-substrate junction organization →	+0.156	+0.318	<.001	.002	3	10
LUNG_NSCLC_LUSC	Positive regulation of supramolecular fiber organization →	+0.097	+0.196	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Cellular component disassembly →	+0.044	+0.186	<.001	<.001	3	10
BONE	Regulation of focal adhesion assembly →	+0.172	+0.318	<.001	.002	3	9
BONE	Regulation of cell-substrate junction assembly →	+0.172	+0.318	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,453 associations by consensus.

Regulation of cell-substrate adhesion by TXNDC2 expression — BONE

Explore this box plot interactively →