TXNDC2

Across TCGA cell cohorts, TXNDC2 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TXNDC2-associated genes across cancer lineages are SPATA19, DAZ2, and WFDC12. Each is linked with TXNDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNDC2-to-partner and partner-to-TXNDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA19 grouped by TXNDC2-low versus TXNDC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC2→partner) and Y-score (partner→TXNDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPATA19 →	+0.022	+5.569	<.001	.001	3	2
STOMACH	DAZ2 →	+0.969	+4.432	.003	.003	3	1
BLOOD_Leukemia	WFDC12 →	+0.244	+4.874	<.001	.002	3	1
BLOOD_Leukemia	OR6B3 →	+0.016	+4.539	<.001	.007	3	1
BLOOD_Leukemia	WFDC11 →	+0.030	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TRIM49B →	+0.158	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

SPATA19 by TXNDC2 expression — BLOOD_Leukemia

Explore this box plot interactively →