TXNDC2

Across TCGA cell cohorts, TXNDC2 mutation is significantly associated with the mutation status of many other genes, with 1,824 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TXNDC2-associated genes across cancer lineages are DELE1, AR, and SH3BP1. Each is linked with TXNDC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TXNDC2-to-partner and partner-to-TXNDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DELE1 grouped by TXNDC2-low versus TXNDC2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC2→partner) and Y-score (partner→TXNDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DELE1 →	+4.977	+4.415	.007	.007	1	4
CNS	AR →	+4.614	+4.614	.006	.006	1	3
BLOOD_Lymphoma	SH3BP1 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	SSTR1 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	LTBP3 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	ZFR →	+5.014	+5.584	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,824 associations by consensus.

DELE1 by TXNDC2 expression — OVARY

Explore this box plot interactively →