TXNDC17

Across TCGA pan-cancer cohorts, TXNDC17 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TXNDC17 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TXNDC17 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TXNDC17 expression acts as an unfavorable survival marker, although some lineages such as OV and UCEC show a favorable association.

UVM, ACC, and KICH are the cancer types where TXNDC17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.446	0.811	<.001	135	view →
ACC	OS	Median	All	0.759	0.972	<.001	123	view →
KICH	OS	Median	All	0.711	1.000	<.001	105	view →
HNSC	DFS	Tertile	III,IV	0.576	0.747	<.001	79	view →
KIRC	DFS	Tertile	IV	0.160	0.485	<.001	73	view →
LGG	DFS	Median	All	0.637	0.840	<.001	50	view →
UCS	DFS	Median	IV	0.367	0.952	.001	42	view →
PAAD	OS	Median	All	0.521	0.697	.001	40	view →
LIHC	OS	Median	III,IV	0.215	0.454	.001	30	view →
CHOL	DFS	Median	All	0.103	0.723	<.001	20	view →
OV	OS	Tertile	All	0.443	0.308	.006	18	view →
SARC	DFS	Quartile	All	0.450	0.655	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TXNDC17–UVM (OS)

Open the UVM breakdown →