TXNDC16

Across TCGA pan-cancer cohorts, TXNDC16 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TXNDC16 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TXNDC16 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TXNDC16 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where TXNDC16 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.223	0.841	.038	8	view →
LUAD	OS	Median	All	0.863	0.618	.026	8	view →
PDAC	OS	Median	All	0.688	1.000	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TXNDC16–HNSC (DFS)

Open the HNSC breakdown →