TXNDC16

Across TCGA patient cohorts, TXNDC16 mutation is significantly associated with the RNA expression of many other genes, with 2,963 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNDC16-associated genes across cancer lineages are RNU6-349P, RN7SKP221, and GAPDHP30. Each is linked with TXNDC16 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNDC16-to-partner and partner-to-TXNDC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-349P grouped by TXNDC16-low versus TXNDC16-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC16→partner) and Y-score (partner→TXNDC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-349P →	+0.302	+8.055	<.001	.007	3	2
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
LUSC	GAPDHP30 →	+0.101	+3.135	<.001	.002	3	2
LUSC	RNU6-1164P →	+0.358	+2.920	.001	.003	3	2
SKCM	MIR8082 →	+0.366	+3.169	<.001	.003	3	2
SKCM	RN7SL155P →	+0.070	+3.292	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,963 associations by consensus.

RNU6-349P by TXNDC16 expression — BRCA

Explore this box plot interactively →