TXNDC16

Across TCGA cell cohorts, TXNDC16 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TXNDC16-associated genes across cancer lineages are DPRX, IL22, and CRYBA4. Each is linked with TXNDC16 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNDC16-to-partner and partner-to-TXNDC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by TXNDC16-low versus TXNDC16-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC16→partner) and Y-score (partner→TXNDC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DPRX →	+0.040	+4.058	<.001	.007	3	2
LUNG_SCLC	IL22 →	+0.062	+4.459	.002	.001	3	1
LUNG_SCLC	CRYBA4 →	+0.119	+3.628	.002	.009	3	1
LUNG_SCLC	KRTAP12-4 →	+0.060	+4.058	<.001	.007	3	1
SOFT_TISSUE	TBATA →	+0.009	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR4X2 →	+0.013	+4.369	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

DPRX by TXNDC16 expression — LUNG_SCLC

Explore this box plot interactively →