TXNDC15

Across TCGA patient cohorts, TXNDC15 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNDC15-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and Ku80. Each is linked with TXNDC15 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNDC15-to-partner and partner-to-TXNDC15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by TXNDC15-low versus TXNDC15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC15→partner) and Y-score (partner→TXNDC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.177	+2.999	.048	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.184	-3.321	.019	.010	3	1
UCEC	Ku80 →	+0.255	+1.887	.020	.031	3	1
UCEC	mTOR →	-0.206	-2.999	.006	.035	3	1
UCEC	Notch1 →	+0.178	+3.700	.006	.001	3	1
UCEC	Raptor →	-0.195	-3.169	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ERK2 by TXNDC15 expression — UCEC

Explore this box plot interactively →