TXNDC11

Across TCGA patient cohorts, TXNDC11 mutation is significantly associated with the RNA expression of many other genes, with 2,574 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNDC11-associated genes across cancer lineages are HARBI1, CDCA2, and PRMT3. Each is linked with TXNDC11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNDC11-to-partner and partner-to-TXNDC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HARBI1 grouped by TXNDC11-low versus TXNDC11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC11→partner) and Y-score (partner→TXNDC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HARBI1 →	+0.384	+2.212	.001	.001	3	2
UCEC	CDCA2 →	+1.069	+2.662	<.001	<.001	3	2
UCEC	PRMT3 →	+0.487	+2.180	.002	.002	3	2
UCEC	PSMD12 →	+0.415	+3.502	.005	.002	3	2
UCEC	POLH-AS1 →	+0.669	+2.839	<.001	.001	3	2
SKCM	CUL1P1 →	+0.028	+3.479	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,574 associations by consensus.

HARBI1 by TXNDC11 expression — UCEC

Explore this box plot interactively →