TXNDC11

Across TCGA patient cohorts, TXNDC11 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNDC11-associated genes across cancer lineages are FoxM1, Cyclin-B1, and EGFR_pY1068. Each is linked with TXNDC11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNDC11-to-partner and partner-to-TXNDC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TXNDC11-low versus TXNDC11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC11→partner) and Y-score (partner→TXNDC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.304	+3.331	.003	.005	3	2
UCEC	Cyclin-B1 →	+0.702	+3.321	.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.297	-2.459	.003	.018	3	1
UCEC	GATA6 →	-0.188	-2.115	.003	.017	3	1
UCEC	INPP4B →	-0.267	-1.874	.040	.049	3	1
UCEC	Ku80 →	+0.261	+2.428	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

FoxM1 by TXNDC11 expression — UCEC

Explore this box plot interactively →