TXN2

Across TCGA pan-cancer cohorts, TXN2 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TXN2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where TXN2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TXN2 is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and COAD are the cancer types where TXN2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TXN2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	−0.808	<.001	12	view →
HNSC	Female	All	−0.830	<.001	11	view →
COAD	Male	All	−0.526	<.001	9	view →
LUAD	Female	All	+0.185	.004	3	view →
OV	All	All	+0.490	.038	2	view →
PDAC	Male	All	+0.459	.014	1	view →
LSCC	Female	III,IV	−0.257	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

TXN2–CCRCC

Open the CCRCC breakdown →