TXLNG

Across TCGA pan-cancer cohorts, TXLNG mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TXLNG’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TXLNG mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TXLNG is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

HNSC, CCRCC, and PDAC are the cancer types where TXLNG tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TXLNG mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.339	<.001	8	view →
CCRCC	All	II,III,IV	+0.133	<.001	6	view →
PDAC	Male	All	−0.168	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

TXLNG–HNSC

Open the HNSC breakdown →