TXLNG

Across TCGA patient cohorts, TXLNG mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXLNG-associated genes across cancer lineages are Notch1, eIF4G, and FOXO3a_pS318_S321. Each is linked with TXLNG in more than 1 cancer types. Because this analysis shows association rather than direction, both TXLNG-to-partner and partner-to-TXLNG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TXLNG-low versus TXLNG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXLNG→partner) and Y-score (partner→TXLNG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.209	+3.469	<.001	.002	3	2
UCEC	eIF4G →	+0.304	+2.459	.014	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.134	-2.415	.007	.003	3	1
UCEC	GAPDH →	+0.437	+3.321	.043	.009	3	1
UCEC	GATA6 →	-0.180	-3.307	.004	.009	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.468	+1.884	.022	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Notch1 by TXLNG expression — UCEC

Explore this box plot interactively →