TXLNA

Across TCGA patient cohorts, TXLNA mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXLNA-associated genes across cancer lineages are EGFR_pY1068, PDCD4, and ATM. Each is linked with TXLNA in more than 2 cancer types. Because this analysis shows association rather than direction, both TXLNA-to-partner and partner-to-TXLNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TXLNA-low versus TXLNA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXLNA→partner) and Y-score (partner→TXLNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.233	-2.115	.033	.019	3	2
UCEC	PDCD4 →	-0.506	-2.312	.013	.034	2	3
UCEC	ATM →	-0.463	-2.115	.019	.019	2	3
UCEC	14-3-3_beta →	-0.108	-2.102	.013	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.196	-2.794	.007	.003	3	1
UCEC	Ku80 →	+0.203	+2.128	.049	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by TXLNA expression — UCEC

Explore this box plot interactively →