TWNK

Across TCGA pan-cancer cohorts, TWNK Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TWNK data layer compared with 29 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TWNK Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TWNK expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

STAD, BRCA, and LUAD are the cancer types where TWNK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	II,III,IV	0.112	0.641	<.001	30	view →
BRCA	OS	Median	III,IV	0.200	0.833	<.001	12	view →
LUAD	DFS	Median	II,III,IV	0.314	0.724	.016	3	view →
SKCM	DFS	Median	II,III,IV	0.803	0.248	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TWNK–STAD (DFS)

Open the STAD breakdown →